Defronzo from the diabetes division, university of texas health science center, san antonio, texas. View and download powerpoint presentations on defronzo ppt. Funnell is an emeritus research scientist with the department of learning health sciences at the university of michigan medical school in ann arbor, mich. Insulin resistance in muscle and liver and impaired insulin secretion represent the core defects in type 2 diabetes. New paradigm for the treatment of type 2 diabetes mellitus misha denham, d. Schematic presentation of the gastrointestinal anatomy after. Insulin resistance in muscle and liver and impaired. Ralph anthony defronzo, md ppt download slideplayer.
Winner of the standing ovation award for best powerpoint templates from presentations magazine. Defronzo from the diabetes division, university of. Living with diabetes this booklet provides information about the steps to managing diabetes by eating healthy, being active, and taking medicines. Pathophysiologic approach to therapy in patients with.
Pathophysiology of type 2 diabetes bruno almeida m. This randomised, doubleblind, phase 3a trial was undertaken at 88 sites in eight countries. American diabetes association professor of medicine georgetown university school of medicine disclosed no conflict of interest newer therapies. Edcs and diabetes exposure to ddt in utero can increase a childs risk of. Includes an overview of diabetes treatment options. From ominous octet to dirty dozen sanjay kalra powerpoint ppt presentation. Pathogenesis of type 2 diabetes the ominous octet islet bcell impaired insulin secretion neurotransmitter dysfunction decreased glucose uptake islet acell increased glucagon secretion increased. Hyperglycemia is a manifestation of these eight pathophysiological abnormalities. Dr ralph defronzo discusses 8 core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture presented in 2008.
Some scientists believe that a childs risk is greater when the parent with type 2 diabetes is the mother. Igt ominous octet type ii dm 8 mechanisms of hyperglycemia death. Ominous octet and egregious eleven in 2009, the pathophysiology of diabetes was introduced as the omi nous octet, which challenged clinicians to think beyond impaired insulin secretion, increased hepatic glucose production, and. Find powerpoint presentations and slides using the power of, find free presentations research about defronzo ppt. Diabetes presentation 2018 by prezi user on prezi next. Patients aged 18 years and older, with type 2 diabetes, an estimated glomerular filtration rate of 3059 mlmin per 173 m 2, and who had been receiving a stable dose of metformin or sulfonylurea, or both, or basal insulin with or without metformin for the past 90 days were eligible.
Pathogenesis of type 2 diabetes mellitus international. New paradigm for the treatment of type 2 diabetes mellitus. Banting lecture from the triumvirate to the ominous. Print diabetes ominous octet flashcards easy notecards. Over the past 20 years, during which increasing attention in the field of type 2 diabetes mellitus t2dm has focused on atherosclerotic complications, heart failure hf has emerged as another serious complication occurring significantly more frequently in people with t2dm. These defects, called the ominous octet, can cause diabetes to change over time and make it difficult to reach your a1c goal. Download figure open in new tab download powerpoint.
To compare recent diabetes guideline updates from the american diabetes associationeuropean association for the study of diabetes. We now understand that there are 8 core defects in the human body that are currently known to adversely affect blood sugar levels in people with diabetes. View and download powerpoint presentations on ominous octet ppt. Pioglitazone, diabetes mellitus, type 2 and piperidines researchgate, the. Two general approaches to the treatment of type 2 diabetes mellitus t2dm have been advocated. Dr ralph defronzo discusses eight core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture presented in 2008. The ominous octet 3 depicting the mechanism and site of action of antidiabetes medications based upon the pathophysiologic disturbances present in t2dm. The multiple complex pathophysiologic defects associated with type 2 diabetes mellitus require that multiple drugs be used in combination to improve the patients overall outcomes, and that treatment should be based on reversal of all known complications, rather than strictly on reducing a1c. In people with type 2 diabetes, there are at least 8 core defects that can affect blood sugar levels.
Defronzo i nsulin resistance in muscle and liver and cell failure represent the core pathophysiologic defects in type 2 diabetes. Comparison of the diabetes guidelines from the adaeasd. From the triumvirate to the ominous octet a new paradigm for the treatment of t2dm. The ominous octet core defects in type 2 diabetes pro. A new paradigm for the treatment of type 2 diabetes mellitus. Dickinson is the diabetes education and management program director and lecturer at teachers college, columbia university in new york, n. These can be used for reference purposes or for inclusion in ones. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Professor of medicine and chief, diabetes division, the university of texas health science center at san antonio uthscsa, deputy director, texas diabetes institute, san antonio, tx, usa. T2 a new paradigm for the treatment of type 2 diabetes mellitus. Doctors and scientists call these 8 core defects the ominous octet.
The time is right for a new classification system for diabetes. The ominous octet washington association of diabetes. Hf is typically an ominous diagnosis in patients with diabetes. Ralph anthony defronzo, md presentation transcript. The ominous octet defronzo r diabetes 2009 metformin ampk. Novel agents for the treatment of type 2 diabetes from 1987 to the present, our understanding of the pathophysiology of type 2 diabetes has expanded from the triumvirate of. Resource preservation of pancreatic betacell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in highrisk hispanic women. Downloadable powerpoint slides that summarizeillustrate topics pertinent to diabetes care. Stanley schwartzs slides series on the state of diabetes in the u. The natural history of type 2 diabetes described above is depicted by a prospective study carried out by felber and colleagues in lausanne, switzerland. Cut out the notecards by cutting along each horizontal dotted.
Bridging the gap from phase i to proofofconcept san francisco, ca tue 8th. Type 2 diabetes mellitus, which is far more common, affecting about 95% of all people diagnosed with diabetes, is a complex process of eight known possible defects known as the ominous octet. A new paradigm for the treatment of type 2 diabetes mellitus ralph a. Prevalence of type 2 diabetes mellitus t2dm, the ominous octet of hyperglycemia in type 2 diabetes mellitus, mechanisms of insulin resistance, diagnostic. Identify current and emerging pharmacotherapy treatments for type 2 diabetes.
Differentiating among incretin agents for type 2 diabetes. Ppt ominous powerpoint presentation free to download. It now is recognized that thecell failure occurs much earlier and is more severe than previously thought. Although the study was originally crosssectional in nature, subjects were followed up for 6 years and shown to progress from one category of glucose intolerance to the next. The ominous octet outlined in orange are the three core pathophysiologies of type 2 diabetes, known as the triumvirate. Print diabetes ominous octet flashcards and study them anytime, anywhere. Slides free downloadable slides for your reference and. These can be used for reference purposes or for inclusion in ones own slide sets. Diabetes is manysided and were learning more about it all the time. Decreased tcf7l2 protein levels in type 2 diabetes mellitus correlate with downregulation of gip and glp1 receptors and impaired betacell function. View ominous octet ppts online, safely and virusfree.
From 1987 to the present, our understanding of the pathophysiology of type 2 diabetes has expanded from the triumvirate of. Relate common adverse drug effects of current diabetes pharmacotherapy to key side effects that should be minimized based on national guidelines. Fold each page in half along the solid vertical line. The word ominous suggests that something bad or unfortunate may happen in the future. Update on diabetes treatment strategies 2017 slideshare. Dr ralph defronzo discusses 8 core defects implicated in the pathogenesis of type 2 diabetes as described during his ominous octet banting lecture. Collectively, these eight players comprise the ominous octet and dictate that. Therapy of type 2 diabetes mellitus, update, part 1.
Displaying powerpoint presentation on the eight core defects in type 2 diabetesthe ominous octet available to view or download. It is well established that type 2 diabetes t2d is a complex metaboliccardiovascular disorder with at least eight distinct pathophysiological disturbances, referred to as the ominous octet. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Efficacy and safety of oral semaglutide in patients with. Diabetes pathophysiology the video demonstrates the mechanism of glp1 and insulin in a simplified, funtolearn manner for clinicians. Collectively, these eight players comprise the ominous octet and dictate that 1 multiple drugs used in combination will be required to correct the multiple pathophysiological defects, 2 treatment should be based upon reversal of known pathogenic abnormalities and not simply on reducing hba 1c, and 3 therapy must be started early to. Find powerpoint presentations and slides using the power of, find free presentations research about ominous octet ppt. The ominous octet of dm2the ominous octet of dm2 islet.
1134 929 1137 1017 1425 801 399 590 372 1235 712 169 1505 1134 732 43 425 370 405 103 191 569 576 80 972 839 492 515 267 260 376 664 965 807 1227 723 759 836 1466 207 1014 1164 1128 228